2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W679754R
    Pentacosafluorotridecanoic Acid (Standard) 72629-94-8
    Pentacosafluorotridecanoic Acid (Standard) is the analytical standard of Pentacosafluorotridecanoic Acid (PFTrDA) (HY-W679754). This product is intended for research and analytical applications.Pentacosafluorotridecanoic Acid is a long-chain perfluoroalkyl carboxylic acid with strong endocrine-disrupting activity. Pentacosafluorotridecanoic Acid exhibits estrogenic effects and disrupts vtg1 transcription as well as sex hormone homeostasis in male Danio rerio. Pentacosafluorotridecanoic Acid disturbs steroidogenesis and HPG axis function in a sex-dependent pattern. Pentacosafluorotridecanoic Acid inhibits CYP17A and CYP11A1 to reduce testosterone and increase E2/T ratio in H295R cells. Pentacosafluorotridecanoic Acid triggers gender-specific immunomodulation after prenatal exposure. Pentacosafluorotridecanoic Acid correlates with lower eczema risk in female infants. Pentacosafluorotridecanoic Acid can be used for the research of endocrine disruption and eczema.
    Pentacosafluorotridecanoic Acid (Standard)
  • HY-W724781A
    Methyl cis-9,10-methylenehexadecanoate 36254-90-7 98%
    Methyl cis-9,10-methylenehexadecanoate is an ester product.
    Methyl cis-9,10-methylenehexadecanoate
  • HY-W777866A
    3-Chloro-2-stearoyloxypropyl (9Z,12Z)-octadeca-9,12-dienoate 1336935-07-9 98%
    3-Chloro-2-(stearoyloxy)propyl (9Z,12Z)-octadeca-9,12-dienoate is an ester product.
    3-Chloro-2-stearoyloxypropyl (9Z,12Z)-octadeca-9,12-dienoate
  • HY-W782236A
    12(S),13(R)-Epoxy-9(Z)-octadecenoic acid 503-07-1 98%
    12(S),13(R)-Epoxy-9(Z)-octadecenoic acid is an ester product.
    12(S),13(R)-Epoxy-9(Z)-octadecenoic acid
  • HY-W955711A
    22:0(2S-OH) Ceramide 1246298-49-6 98%
    22:0(2S-OH) Ceramide is a ceramide.
    22:0(2S-OH) Ceramide
  • HY-113308AS1
    Taurolithocholic Acid-d5 sodium salt 1265476-97-8 98%
    Taurolithocholic Acid-d5 (sodium) is the deuterium labeled Taurolithocholic acid sodium salt. Taurolithocholic Acid sodium salt is an orally active bile acid and antiviral agent. Taurolithocholic Acid sodium salt upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic Acid sodium salt also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic Acid sodium salt serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic Acid sodium salt shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic Acid sodium salt not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis.
    Taurolithocholic Acid-d5 sodium salt
  • HY-W009162S1
    Cytidine 5′-monophosphate-13C9 dilithium 98%
    Cytidine 5′-monophosphate-13C9 (5'-Cytidylic acid-13C9 dilithium; 5'-CMP-13C9) dilithium is 13C-labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.
    Cytidine 5′-monophosphate-13C9 dilithium
  • HY-W009204S5
    Fmoc-Ala-OH-13C3 765259-05-0 98.5%
    Fmoc-Ala-OH-13C3 is a 13C-labeled Fmoc-Ala-OH (HY-W009204). Fmoc-Ala-OH is an alanine derivative.
    Fmoc-Ala-OH-13C3
  • HY-W009371CR
    D-Ribose 5-phosphate disodium dihydrate (Standard) 207671-46-3 98%
    D-Ribose 5-phosphate (disodium dihydrate) (Standard) is the analytical standard of D-Ribose 5-phosphate (disodium dihydrate) (HY-W009371C). This product is intended for research and analytical applications. D-Ribose 5-phosphate disodium dihydrate is an intermediate of the oxidative branch of the pentose phosphate pathway (PPP) and an end product of the nonoxidative branch of the PPP. D-Ribose 5-phosphate is used in the synthesis of nucleotides and nucleic acids.
    D-Ribose 5-phosphate disodium dihydrate (Standard)
  • HY-W009390AR
    4,4'-Disulfanediylbis(2-aminobutanoic acid) (Standard) 462-10-2 98%
    4,4'-Disulfanediylbis(2-aminobutanoic acid) (Standard) is the analytical standard of 4,4'-Disulfanediylbis(2-aminobutanoic acid) (HY-W009390A). This product is intended for research and analytical applications. 4,4'-Disulfanediylbis(2-aminobutanoic acid) is an endogenous metabolite.
    4,4'-Disulfanediylbis(2-aminobutanoic acid) (Standard)
  • HY-W010450S5
    Thymine-13C5,15N2 2483830-13-1 98%
    Thymine-13C5,15N2 (5-Methyluacil-13C5,15N2) is 13C and 15N labeled Thymine. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM.
    Thymine-13C5,15N2
  • HY-W010476S1
    2,3,5-Trimethylpyrazine-d3 1082582-30-6 98%
    2,3,5-Trimethylpyrazine-d3 is deuterated labeled 2,3,5-Trimethylpyrazine (HY-W010476). 2,3,5-Trimethylpyrazine is an endogenous metabolite.
    2,3,5-Trimethylpyrazine-d3
  • HY-W010489S1
    2-Phenylacetaldehyde-13C2 1083053-39-7 98%
    2-Phenylacetaldehyde-13C2 is 13C labeled 2-Phenylacetaldehyde (HY-W010489). 2-Phenylacetaldehyde is an endogenous metabolite.
    2-Phenylacetaldehyde-13C2
  • HY-W011053GL
    Neotame (GMP Like) 165450-17-9
    Neotame (GMP Like) is the GMP Like class Neotame (HY-W011053) that can be used as pharmaceutical excipients. Neotame is a derivative of Aspartame (HY-B0361) and is a flavor enhancer and low-caloric, non-nutritive, high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame causes intestinal epithelial cell death at high concentrations. Neotame induces Apoptosis of Caco-2 cells.
    Neotame (GMP Like)
  • HY-W011297S2
    Methyl arachidonate-13C4 2692624-39-6 98%
    Methyl arachidonate-13C4 (Arachidonic acid methyl ester-13C4) is 13C labeled Methyl arachidonate. Methyl arachidonate (Arachidonic acid methyl ester) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of arachidonic acid with methanol. Methyl arachidonate has activity of human blood serum metabolite.
    Methyl arachidonate-13C4
  • HY-W011297S3
    Methyl arachidonate-13C5 98%
    Methyl arachidonate-13C5 (Arachidonic acid methyl ester-13C5) is 13C labeled Methyl arachidonate. Methyl arachidonate (Arachidonic acid methyl ester) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of arachidonic acid with methanol. Methyl arachidonate has activity of human blood serum metabolite.
    Methyl arachidonate-13C5
  • HY-W011683S7
    2'-Deoxyadenosine monohydrate-15N5 98%
    2'-Deoxyadenosine monohydrate-15N5 is the 15N labeled 2'-Deoxyadenosine monohydrate (HY-W011683). 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer.
    2'-Deoxyadenosine monohydrate-15N5
  • HY-W011704AR
    Phosphoenolpyruvic acid tricyclohexylammoniu​m salt (Standard) 35556-70-8 98%
    Phosphoenolpyruvic acid (Phosphoenolpyruvate) tricyclohexylammoniu​m salt is a glycolysis metabolite with a high-energy phosphate group. Phosphoenolpyruvic acid tricyclohexylammoniu​m salt is involved in glycolysis and gluconeogenesis, and used as energy source to produce ATP, under the energy-limited conditions. Phosphoenolpyruvic acid tricyclohexylammoniu​m salt also exhibits cytoprotective and anti-oxidative properties.
    Phosphoenolpyruvic acid tricyclohexylammoniu​m salt (Standard)
  • HY-W012241S1
    Dodecanedioic acid-d4 97543-02-7 99.95%
    Dodecanedioic acid-d4 is the deuterium labeled Dodecanedioic acid (HY-W012241). Dodecanedioic acid is an orally active straight-chain dicarboxylic acid. As an alternative energy substrate between lipids and carbohydrates, Dodecanedioic acid can be rapidly oxidized during exercise, reducing muscle fatigue without stimulating insulin secretion. Dodecanedioic acid also exhibits blood glucose-lowering activity in non-insulin-dependent diabetes mellitus.
    Dodecanedioic acid-d4
  • HY-W013049S2
    Docosanoic acid-d2 71607-34-6 98%
    Docosanoic acid-d2 (Behenic acid-d2) is deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans.
    Docosanoic acid-d2
Cat. No. Product Name / Synonyms Application Reactivity